Not known Facts About methadone intoxication
[sixty one] Like a lot of other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with diverse potency. Dextromethadone, and that is significantly less powerful as an opioid, is more strong at blocking the hERG channel with an IC50 of ~12 &